Tissue Transglutaminase (tTG) is an enzyme found in your body's tissues. When you have coeliac disease, your immune system produces antibodies against tTG in response to gluten. Testing for these antibodies is the primary screening method for coeliac disease, making it a crucial first step in understanding your body's reaction to gluten.

This test is ideal for anyone experiencing:

• Persistent bloating, abdominal pain, or digestive discomfort

• Unexplained diarrhea or constipation

• Fatigue and nutritional deficiencies

• A family history of coeliac disease

• Suspected gluten sensitivity

This test measures tTG antibodies in your blood, which can indicate whether your immune system is reacting to gluten. A positive result suggests coeliac disease may be present, while a negative result makes it less likely. Important: This is a screening test and any positive results should be followed up with your GP for confirmatory testing.

Yes, this is crucial. You must be eating gluten regularly (at least one slice of bread or equivalent daily) for several weeks before the test. If you've already removed gluten from your diet, antibody levels may drop, leading to a false negative result. Do not start a gluten-free diet before testing.

Preparation is straightforward:

• Continue eating gluten: Do not start a gluten-free diet before testing

• No fasting required: You can eat and drink normally

• Be well: Avoid testing during acute illness

• Hydrate: Drink water beforehand

• Bring ID: Photo ID and order confirmation email

You will receive secure online results with a GP-written explanation from Brooksby Medical within 2–3 working days.

A positive result indicates the presence of tTG antibodies and suggests coeliac disease may be present. We will explain the significance and recommend next steps, which typically include referral to your GP for confirmatory tests (usually an endoscopy biopsy) before starting a gluten-free diet.