Tiredness & Fatigue Blood Test · GP-led

Why am I always tired? Find out properly.

A 50-biomarker venous blood test for unexplained tiredness, with a one-to-one consultation with Dr Coleman to interpret your results. Built around the NICE Clinical Knowledge Summary on tiredness in adults.

CQC-registeredUKAS-accredited UK labDoctor consultation includedResults in 2–3 working days
The evidence base

The bloods NICE recommends for unexplained fatigue, in one draw.

The NICE Clinical Knowledge Summary lists a specific set of blood tests for the assessment of tiredness in adults. This panel includes every one of them, run together in a single venous draw, and interpreted in the context of a doctor consultation — exactly the way a GP appointment would work.

Two markers go beyond the standard guideline because the evidence supports them: active B12 instead of total B12 (more reliable in the low-normal range), and full thyroid antibodies alongside TSH (catches autoimmune thyroid disease that basic thyroid tests miss).

Read the NICE CKS guideline →
NICE-recommended testThis panel
Full blood count + iron stores
Inflammation marker
Liver function
Kidney function
Thyroid functionEnhanced — full antibody panel
Diabetes (HbA1c)
Coeliac screen
Muscle enzyme
Calcium
Vitamin D
Vitamin B12 + folateEnhanced — active B12
Cortisol
Magnesium
Symptoms a fatigue blood test investigates

Tired all the time? If any of these sound familiar, it’s worth investigating.

Most fatigue has a cause. Some causes are lifestyle. Some are mood. A handful are physical and worth looking at — and almost all of those show up in blood.

Tiredness that doesn’t lift, even after a good night’s sleep
Brain fog or trouble concentrating
Low energy that’s changed your daily life
Symptoms that get worse after physical or mental effort
Cold hands and feet, or feeling the cold more than others
Hair shedding, dry skin, or unexplained weight changes
Muscle aches, weakness, or unexplained cramping
Persistent low mood alongside the tiredness
Dr James Coleman
Your doctor

Dr James Coleman

BSc, MB ChB, MRCGP · Practising GP · Founder, Brooksby Medical
These are the bloods NICE recommends for unexplained fatigue. I run them together in one draw, then we go through the results properly — the way a good GP appointment should work.
How it works

From order to clarity in days, not months.

1

Order your test

Choose online in minutes. Your kit ships the same working day.

2

Quick questionnaire

A short medical and symptom check (PHQ-9, GAD-7, sleep, red flags) so the panel is interpreted in context.

3

Collect your sample

Take the kit to a phlebotomist, attend a partner clinic, or have a nurse come to you.

4

Your GP-written report

Reviewed by a practising GP. Delivered to your secure portal within 2–3 working days.

5

Book your doctor review

Receive a link to book a private call with your doctor to discuss your results and the next steps that make sense for you.

What you actually get

An explanation, not a number on a screen.

Most online tests give you a dashboard. You get a written report from a practising GP that explains every result in plain English, and a consultation to talk through what (if anything) needs doing next.

  • ✓ Personal interpretation by Dr Coleman
  • ✓ Clear next steps, not just numbers
  • ✓ One-to-one video consultation included
  • ✓ Shareable with your NHS GP if you want
Brooksby MedicalDoctor reviewed
Ferritin
18µg/L
Free T4
14.2pmol/L
Dr Coleman's note: Your ferritin is at the low end and is the most likely contributor to your symptoms. Thyroid is normal so we can rule that out. We’ll talk through iron replacement options in your consultation, and recheck in 12 weeks.
Illustrative example. Your report shows your real values and a personal interpretation.
Every marker explained

What this fatigue blood test actually measures.

Every marker explained in plain English, with the NICE CKS provenance so you can see exactly what you’re getting.

Active Vitamin B12

Brooksby enhancement

The biologically usable form of B12, rather than total B12. Catches early deficiency that a standard total-B12 test can miss — useful when fatigue, pins-and-needles or brain fog are present.

Ferritin

NICE CKS — first-line

Your iron stores. Low ferritin is one of the commonest physical causes of fatigue, and is often missed when only haemoglobin is checked.

Folate

NICE CKS — additional

Essential for red blood cell production. Low folate causes a specific type of anaemia that often goes hand-in-hand with B12 deficiency.

Magnesium

NICE CKS — first-line

Supports muscle function, sleep, and energy production. Deficiency is associated with fatigue, cramps, and disturbed sleep.

Vitamin D

NICE CKS — additional

Widespread deficiency in the UK, particularly in winter. Low vitamin D is associated with fatigue, low mood, and muscle weakness.

Full Blood Count

NICE CKS — first-line

Twenty markers covering red cells (anaemia), white cells (infection, immune issues) and platelets. The starting point for any fatigue workup.

HbA1c

NICE CKS — first-line

Your average blood sugar over the last 3 months. Both diabetes and pre-diabetes can present with fatigue before any other symptom appears.

Kidney function

NICE CKS — first-line

Six markers covering how well your kidneys are working. Hidden kidney problems are an uncommon but important cause of fatigue.

Liver function

NICE CKS — first-line

Eight markers covering liver health. Liver issues can cause fatigue long before they cause obvious symptoms.

Thyroid (full panel)

Brooksby enhancement

A standard fatigue panel checks TSH only. We run the full thyroid panel — including the antibodies that signal autoimmune thyroid disease — which a basic TSH would miss.

Cortisol

NICE CKS — additional

The body’s main stress hormone. Both very low cortisol and chronically elevated levels can drive fatigue.

Calcium

NICE CKS — first-line

Both high and low calcium can cause tiredness, mood changes and muscle weakness — and often go undetected without a proper panel.

Muscle enzyme (CK)

NICE CKS — first-line

Useful when fatigue comes with muscle aches or weakness — raised levels can suggest a muscle disorder, low levels can reflect very low activity.

Inflammation marker (hs-CRP)

NICE CKS — first-line

A sensitive measure of low-grade inflammation. Persistently raised levels can point to a hidden inflammatory or autoimmune condition.

Coeliac screen

NICE CKS — first-line

Coeliac disease is a frequently-missed cause of fatigue, even without obvious gut symptoms. NICE specifically lists this in the fatigue workup.

Choose how you'd like your sample taken

Pick the option that suits you. The test is the same — only the way we collect your sample changes.

Tiredness & Fatigue Blood Test
Total
£199
One-off purchase. Doctor's report included.
  • GP-written interpretation by Dr James Coleman
  • UKAS-accredited UK laboratory
  • Results in 2–3 working days
How would you like your sample taken?
Most popular
Arrange your own blood draw
Venous collection kit posted to your door. Take it to your own phlebotomist or nurse, then return the sample in the prepaid envelope.
Included
Home nurse visit
A qualified phlebotomist comes to you at a time that suits.
+£65
Partner clinic (Superdrug)
70+ UK locations. Professional venous blood draw in about 10 minutes.
+£40
Total£199

No subscription. No hidden fees. Same-day dispatch. Ordering more than one test? Place each order separately — each one ships as its own kit with its own doctor's report.

What happens after you order
1
Kit arrives in 1–2 days. Plain box, no branding.
2
Give your sample. Take the kit to any phlebotomist or nurse, then post the sample back in the prepaid envelope.
3
Results in 2–3 working days. Dr Coleman sends a plain-English report.
If your result flags anything, Dr Coleman will tell you exactly what it means and what to do next.
Plain box, no branding Results stay private Same-day dispatch No referral needed Doctor's report included CQC registered
Tiredness & Fatigue Blood Test £199Doctor's report in 2–3 days
Order
Why choose this fatigue blood test

Built on guidance, not marketing.

Most online fatigue tests are a dashboard with a price tag. This is a GP-led service that happens to use blood tests as its tool.

Built on NICE CKS

The investigations the official guideline lists for unexplained fatigue, run together — not a marketing-led panel.

Doctor consultation included

A one-to-one video consultation with Dr Coleman to interpret your results — not an extra charge.

A named GP, not a pool

Every report is written and signed by Dr Coleman personally. Same doctor for the consultation.

UKAS-accredited UK lab

Same accreditation standard as NHS hospital labs. Plain packaging, encrypted data, no marketing follow-ups.

How this compares

Brooksby
Medichecks
Forth
Thriva
Built on NICE CKS
Doctor consultation included
Active B12 (not total)
Full thyroid antibodies
One-off, no subscription
Subscribe
UKAS-accredited UK lab

Comparison based on competitor product pages at time of writing. Brand names and trade marks are the property of their respective owners.

Common questions

What you’re probably wondering.

Why am I tired all the time?

Persistent tiredness has dozens of possible causes, but most fall into four groups: lifestyle (sleep, alcohol, stress, exercise), mood (depression and anxiety are the single most common cause), physical conditions detectable on blood tests (low iron, thyroid problems, B12 deficiency, diabetes, vitamin D deficiency, coeliac disease, low cortisol), and rarer underlying conditions like ME/CFS. Ruling out the physical causes is exactly what this panel does — and the consultation with Dr Coleman captures the lifestyle and mood factors that no blood test can show.

What blood tests should I have for tiredness?

The NICE Clinical Knowledge Summary for tiredness in adults lists the investigations a GP would consider: full blood count and iron stores, inflammation markers, liver function, kidney function, thyroid function, diabetes screen (HbA1c), coeliac screen, muscle enzyme, calcium, vitamin D, vitamin B12 and folate, magnesium, and cortisol. This panel runs all of those together in one venous draw, with two evidence-based enhancements: active B12 instead of total B12, and full thyroid antibodies alongside TSH.

Can a blood test tell me why I’m always tired?

A blood test alone changes management in only about 5% of fatigue cases — most causes show up in history rather than blood. That’s why this is a clinical service, not just a panel. The pre-test questionnaire and consultation with Dr Coleman cover the other 95%: depression, anxiety, sleep apnoea, lifestyle factors and red-flag symptoms. Together, the bloods plus the assessment cover the full NICE CKS workup.

How can I get a private blood test for tiredness in the UK?

Order online, choose how you want your sample drawn (your own phlebotomist, a partner clinic across the UK, or a home nurse visit), and we ship the kit the same working day. The £199 covers the panel, the lab analysis at a UKAS-accredited UK lab, the GP-written report, and a one-to-one consultation with Dr Coleman. Reports come back in 2–3 working days.

What does the NHS do for unexplained tiredness?

A typical NHS GP appointment for fatigue includes a history, an examination, and a focused set of bloods chosen on clinical judgement. NICE guidance recognises that not every patient needs every test, and the threshold for ordering depends on the consultation. This service is built around the same NICE CKS guideline — the difference is convenience: we run the full evidence-based panel in one draw, with a 30-minute consultation rather than the 10 minutes a busy NHS appointment usually allows.

Why these specific markers?

The panel was built around the NICE Clinical Knowledge Summary (CKS) for the assessment of tiredness in adults. Every blood test the CKS lists for fatigue is included. Two markers go beyond the basic guideline — active B12 (more reliable than total B12) and full thyroid antibodies (catches autoimmune thyroid disease) — because both genuinely change how fatigue is investigated.

Is this NICE-endorsed?

No, and we wouldn’t claim that — NICE doesn’t endorse private services. What is true: the investigations on this panel are the ones NICE CKS recommends for the assessment of unexplained tiredness in adults. The panel is aligned with the guideline; the service is independent of NICE.

How is this different from a Medichecks or Forth fatigue test?

Comparable panels online run a similar set of markers. Two practical differences: this one includes a one-to-one consultation with Dr Coleman to interpret your results in clinical context (most others charge extra or send a written report only), and it uses active B12 plus full thyroid antibodies rather than the basic versions.

Will this diagnose ME/CFS?

No single blood test diagnoses ME/CFS. The pre-test questionnaire screens for the cardinal features (post-exertional malaise, unrefreshing sleep, cognitive symptoms, duration over 3 months), and the panel rules out the physical conditions that need to be excluded before that diagnosis can be made. If your symptoms fit the ME/CFS pattern, Dr Coleman will discuss the appropriate next steps in your consultation.

What if my mood questionnaire flags?

Depression is the most common cause of unexplained tiredness — far more common than anything bloods can detect. The pre-test questionnaire includes the validated PHQ-9 and GAD-7 screens. If either flags significantly, Dr Coleman will be in touch personally to discuss what you’ve told us and signpost you to local support. Your kit is dispatched as normal — disclosing low mood doesn’t stop you having the test.

Is the consultation included?

Yes. The £199 price covers the kit, lab analysis, written report, and a one-to-one consultation with Dr Coleman to talk through your results. There’s no separate fee for the consultation.

How quickly do I get my results?

Most reports are ready within 2–3 working days of your sample arriving at our UKAS-accredited lab. You’ll get an email when the report is in your secure portal, with a link to book your consultation slot.

What if I’ve already had blood tests done by my GP?

Bring them to the consultation. Dr Coleman will interpret your existing results alongside the new ones, so you’re not paying to repeat tests you already have. If your GP panel was limited to a basic set, the additional markers here often reveal what was missed.

Where can I get the blood drawn?

Three options at checkout: arrange your own draw at any phlebotomist, GP surgery, clinic or pharmacy that offers it; book at one of our partner clinics across the UK; or arrange a home nurse visit. The kit is posted to you in plain packaging once you order.

Is my data kept private?

Yes. All data is encrypted at rest and processed in the UK in line with GDPR. Packaging is plain. Results go to you and to Dr Coleman only — they’re not shared, sold, or used for marketing.

Ready when you are

Find out what’s actually going on.

50 biomarkers in one venous draw. Reviewed by a practising GP. Your one-to-one consultation included. £199.

Order your test — £199